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China Health & Science

‘Cecolin’ Is Here: First Made-in-China HPV Vaccine Priced at US$47

China is the third country in the world to produce its own HPV vaccine, and it is cheaper than its foreign counterparts.

Manya Koetse

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While Chinese media praise Cecolin for being China’s first domestically produced HPV vaccine, Chinese social media users are more concerned with its price, quality, and availability.

In the first week of 2020, the first China-made HPV vaccine was approved by Chinese drug regulators. The domestically produced HPV vaccine became a major topic of discussion on Chinese social media. On Weibo alone, the topic received more than 580 million views since early January.

The human papillomavirus (HPV) vaccine prevents infection with the specific viral infection that causes cervical cancer. The earliest HPV vaccine, ‘Gardasil’ by American multinational pharmaceutical company Merck & Co., first became available in 2006. Along with Pfizer’s ‘Prevnar 13’ – the vaccine deployed for the prevention of pneumococcal pneumonia – Gardasil is among the world’s best-selling vaccines.

With the introduction of the first Chinese HPV vaccine, the virtual monopoly position of Merck’s vaccine might now change as the Chinese vaccination is entering the market.

The Chinese vaccine is named ‘Cecolin’ (馨可宁), and was co-developed by drug maker Innovax (万泰沧海生物技术) and Xiamen University. It is intended for girls and women aged 9-14 (two shots needed) and 15-45 (three shots needed). According to CGTN, some 8 million shots will be produced in China in 2020.

Gardasil and Cecolin are not entirely the same, however. Gardasil is a so-called quadrivalent vaccine, which targets four different antigens (HPV types 6, 11, 16 and 18), while Cecolin is a bivalent vaccine only protecting against HPV 16 and 18 types, the two most common viruses leading to cervical cancer. Another type of HPV vaccine is the nonavalent kind, the Gardasil 9 vaccine, preventing diseases caused by HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58.

Nearly all sexually active people will be exposed to HPV at some point in their life, and if girls and women are given the vaccine before any natural infection with HPV, the vaccines have been shown to protect against pre-cancer of the cervix. Males can also get the quadrivalent and nonavalent HPV vaccines to protect against genital warts, anal precancers, or the spread of HPV to sexual partners.

While Chinese media emphasize the fact that China is now the third country in the world, after US and UK, to succeed in producing its own HPV vaccine, one of the topics receiving the most attention on Chinese social media is the price of the Cecolin vaccine.

Cecolin is currently priced at 329 yuan (US$47) per shot, which is considerably cheaper than the approximate $250 per dose of the Gardasil vaccine in the United States.

The nonavalent vaccine costs about 1300 yuan or more per shot in China ($186+), with the quadrivalent Gardasil being priced at approximately 800 yuan per shot ($115), and the imported bivalent vaccine costing 600 yuan per dose ($86).

Weibo user shares receipt of 9-valent vaccine, 1338 yuan per dose.

Many Weibo commenters praise the arrival of the Chinese vaccine and its relatively low price. A complete vaccination programme would now only be either 660 or 1000 yuan ($94/$143, depending on needing two or three shots) instead of $260 or more.

“Whoa that’s cheap!” some commenters write, with others saying: “This makes it possible for the poorer girls to get their shots.”

But there is also a lot of discussion on the quality of the vaccine, and whether the bivalent vaccine is effective enough (for clarity -the two HPV types the vaccine protects against causes 84.5% of all cervical cancers in China). Some Weibo users say they would still like to get the more expensive nonavalent vaccine instead – even if they will need to spend around 4000 yuan ($570) on their completed shots.

Other commenters are most concerned with the general availability of HPV vaccines in China, as there is still a shortage of vaccinations.

The imported HPV vaccine was issued 1,46 million times in 2017, going up to 7 million shots in 2018 and 8,7 million in 2019. On Weibo, some commenters say they have previously gone to Hong Kong to get their shot.

One user from Nanjing writes: “I made an appointment for my site and needed to wait for four months, I finally got it. I don’t want to wait around for the domestic shot to become available here.”

A Weibo user from Liaoning is appreciative that those who want to have the vaccine now have more options: “If you can financially afford it, you can choose the nonavalent vaccines, if you can’t afford it, you can get the quadrivalent or bivalent ones.”

Starting from May of 2020, Cecolin will be available at community hospitals across various regions in China.

By Manya Koetse
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©2020 Whatsonweibo. All rights reserved. Do not reproduce our content without permission – you can contact us at info@whatsonweibo.com.

Manya Koetse is the editor-in-chief of www.whatsonweibo.com. She is a writer and consultant (Sinologist, MPhil) on social trends in China, with a focus on social media and digital developments, popular culture, and gender issues. Contact at manya@whatsonweibo.com, or follow on Twitter.

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China Health & Science

Chinese Doctor Knocks Herself Out in Controversial Self-Experiment

Dr. Chen wanted to warn about the dangers of sevoflurane and other drugs.

Manya Koetse

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A female doctor has become a topic of discussion on Chinese social media for her self-experimentation with anesthesia.

Dr. Chen (陈大夫), a Nanjing doctor who works in the Obstetrics and Gynecology department, conducted the experiment in response to an ongoing discussion on whether or not a handkerchief dipped in inhalation anesthetics could cause immediate unconsciousness (“一捂就晕”).

The discussion was triggered by news of the death of a 23-year-old woman from Foshan, Guangdong Province, on February 8. The recent college graduate was found in a hotel room and it was later ruled that the cause of death was acute respiratory failure due to sevoflurane toxicity. The victim’s company supervisor, a 39-year-old man named Peng, is now suspected of fatally sedating and raping the young woman.

The case led to speculation among netizens whether or not sevoflurane could have knocked out the woman in seconds. There have been ongoing debates on the effects of general anesthetics used to sedate unsuspected victims, with some specialists arguing that it is not so easy to make someone slip into unconsciousness within a matter of seconds – saying it would take much longer than and only if an unusually high dosage is used.

Dr. Chen posted on February 10 that she was certain that it is possible for certain inhalation anesthetics to immediately make someone pass out, but her claim was refuted by others. The popular Weibo blogger Jiangning Popo (@江宁婆婆), a police officer, was one of the persons involved in the discussion claiming Chen was wrong.

Dr. Chen is active on Weibo under the handle @妇产科的陈大夫, and with over two million followers on her account, she is somewhat of a ‘celebrity’ doctor.

Instead of spending time arguing back and forth on the internet, Dr. Chen decided to put the issue to the test herself with an unopened bottle of sevoflurane that she had previously purchased for the planned sterilization of her dog. The sevoflurane had already passed its expiry date.

On February 16, Dr. Chen then asked someone else to film her doing the self-experiment and she posted the video on Weibo, in which she inhaled sevoflurane on a cloth. The doctor soon passed out in the video, which has since been deleted.

The experiment in the video lasts 64 seconds, and shows Chen:

– 00:01-00:06 Opening the bottle of sevoflurane
– 00:07-00:12 Preparing a cloth
– 00:13-00:23 Putting the sevoflurane on the cloth
– 00:23-00:26 Closing the cap of the bottle
– 00:27-00:28 Putting the cloth on her mouth and nose
– 00:29-01:33 = the time frame of losing consciousness (with first symptoms starting at 0:44) to going limp and falling on the floor (1:20) and being completely unconscious (1:21-1:33).

Dr. Chen’s experiment immediately sparked controversy after she posted the video on social media.

Although sevoflurane is a prescription drug and a controlled substance, it is also sold online as a type of drug. According to The Paper, the number of rape cases in China facilitated by drugs have risen over the past three years, with many ‘date rape drugs’ being sold and bought over the internet.

With sevoflurane being a controlled substance, Dr. Chen’s video triggered discussions on whether or not she was actually involving in a criminal act by doing the self-experiment. She also received criticism from within the medical community that she used this medication outside of the hospital environment.

Dr. Chen soon deleted the video herself and then called the police to personally explain and apologize for the incident, with the news soon going viral (#女医生拿自己做实验后报警并致歉#, 270 million views).

But despite the controversy, the doctor still defends her actions to some extend. Although Chen stated on February 17 that her self-experiment was “not right,” dangerous, and should never be imitated by anyone, she later also explained on her Weibo page that she thinks sevoflurane as a prescription drug is too easy to get your hands on and that the existing laws to prevent people from buying it are too weak.

The doctor has succeeded in raising public awareness on the dangers of these kinds of drugs. She also reminds both women and men never to leave their drink unattended, as the dangers of someone slipping something in your drink are real and the consequences can be grave.

As the incident has gone trending on Chinese social media, many commenters praise Dr. Chen for her experiment, while others also praise her for being transparent and admitting her mistakes.

 
By Manya Koetse
with contributions by Miranda Barnes

Spotted a mistake or want to add something? Please let us know in comments below or email us. First-time commenters, please be patient – we will have to manually approve your comment before it appears.

©2021 Whatsonweibo. All rights reserved. Do not reproduce our content without permission – you can contact us at info@whatsonweibo.com.

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China Health & Science

Applying China’s New Civil Code, Shanghai Court Annuls Marriage after Husband Hides HIV-positive Status from Wife

The court case triggered discussions on the need for premarital health checks.

Manya Koetse

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Jiang is HIV-positive but did not mention his status to his partner before getting married. Under China’s new civil code, the marriage is now annulled.

On January 4, a Shanghai court applied the new rules of China’s Civil Code for the first time to annul a marriage.

The Civil Code of the People’s Republic of China was adopted by the third session of the 13th National People’s Congress in May of last year and is effective since January 1st 2021. Some experts within China call the law a “milestone legislation” that will better protect people’s civil rights.

On Monday, January 4, a landmark court case in which the new civil code was applied for the first time in Shanghai went trending on Chinese social media.

The case involves a married couple of which the husband had failed to inform his wife that he was HIV positive before getting married.

In June of 2020, Mr. Jiang and Ms. Li got married after Li became pregnant. Afterward, Jiang confessed that he had been HIV-positive for multiple years, and was taking medication to control his disease.

Jiang alleged that, due to his medication, there was effectively no risk of transmitting HIV to his partner. But Li, who did not contract HIV, could not accept the situation and decided to terminate her pregnancy and applied for a marriage annulment.

Under the new civil code, annulment of marriage is possible when a partner who is “seriously ill” – which now includes HIV/AIDS – fails to inform their fiance of their condition before getting married.

Since Jiang had not informed his wife of his condition before tying the knot, the Shanghai Minhang Court ruled in Li’s favor and annulled the marriage.

On Weibo, the case has attracted a lot of attention, with one hashtag about the case (#男方婚前患艾滋未告知婚姻关系被撤销#) attracting 690 million views on Monday.

The news item also led to another hashtag gaining many views: “The Need for Premarital Medical Examination” (#婚前体检的必要性#) had 200 million views on its hashtag page on Monday.

One popular relationship blogger (@感情感分析异地恋) argues that the Shanghai court case shows the importance of couples getting a medical examination before getting married: “It’s not to discriminate against those who are HIV positive or who are suffering from other illnesses, but it’s about informing your partner about these things before getting married.”

Premarital health checks were previously compulsory in China, but these examinations are no longer required since 2003. Many couples do still go for premarital health checkups. According to Xinhua, over 61% of Chinese couples had a medical examination before getting married in 2018.

Although the application of China’s new civil code is generally praised by Weibo users in this case, it has previously also received a lot of negative attention. The new law also introduced a mandatory 30-day “cooling off” period for couples seeking divorce.

This “cooling off” period is seen as harmful to those who are suffering abuse within marriage and already have difficulties in leaving their abusive partner. The case of Lamu, a Tibetan vlogger who died after her husband set her on fire, also led to more online discussions of the “cooling off” period and how it makes women more vulnerable within their marriage.

By Manya Koetse

Spotted a mistake or want to add something? Please let us know in comments below or email us. First-time commenters, please be patient – we will have to manually approve your comment before it appears.

©2021 Whatsonweibo. All rights reserved. Do not reproduce our content without permission – you can contact us at info@whatsonweibo.com.

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